After leaving the Cayman Islands to study screenwriting at the University of Southern California (USC), Frank E made his debut with a short film, SWALLOW, which was an official Sundance selection and later acquired by HBO. Shortly after, Flowers returned to his homeland to direct the independent-thriller, HAVEN, starring Orlando Bloom, Zoe Saldaña, Anthony Mackie, and the late, 

Bill Paxton. In 2013, Flowers revisited Sundance with METRO MANILA, which he co-wrote for director Sean Ellis. METRO went on to win the audience award at Sundance and was nominated for a BAFTA. Frank E maintains a strong commitment to advancing Caymanian culture in film by serving as Chairperson of the Cayman Islands Film Commission board. He is also a cofounder of the SWIM FREE program which mandates life saving swim lessons for all students in the Cayman public primary schools.  As a screenwriter, Flowers scripted SHOOTING STARS about the high school years of LeBron James for Universal/Peacock. He also co-wrote the BOB MARLEY: ONE LOVE biopic for Paramount. Frank E's latest film THE BLUFF, from the Russo Brothers' AGBO and Cinestar Pictures, was released in February 2026 where it debuted at Number 1 on Amazon Prime.