After leaving the Cayman Islands to study screenwriting at the University of Southern California (USC), Frank E made his debut with a short film, SWALLOW, which was an official Sundance selection and later acquired by HBO. Shortly after, Flowers returned to his homeland to direct the independent-thriller, HAVEN, starring Orlando Bloom, Zoe Saldaña, Anthony Mackie, and the late, 

Bill Paxton. In 2013, Flowers revisited Sundance with METRO MANILA, which he co-wrote for director Sean Ellis. METRO went on to be nominated for a BAFTA and was also Great Britain's official submission to the 86th Academy Awards. After losing his mother, Eve Flowers, to leukemia Frank E collaborated with a number of prominent actors and activists to launch a social awareness campaign called “CASTING FOR A HERO”, highlighting the lack of diversity in bone marrow donors worldwide. Frank E maintains a strong commitment to advancing Caymanian culture in film by serving as Chairperson of the Cayman Islands Film Commission. As a screenwriter, Flowers scripted SHOOTING STARS about the high school years of LeBron James for Universal/Peacock. He also co-wrote the BOB MARLEY: ONE LOVE biopic for director Reinaldo Marcus Green which Paramount is releasing in 2024. Frank E is currently attached to direct THE BLUFF with the Russo Brothers' AGBO and Cinestar Pictures.